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1970年有人报告在无肝炎临床表现或无生化改变的小婴儿血内测出HBsAg;同年另有人报告1例新生儿肝炎,并在患儿和其母亲血内均测出HBsAg;1973年Kattamic等又报告两例新生儿肝炎均伴有HBAg;以后已知HBV能由患HBsAg阳性或无症状慢性HBsAg携带者的孕妇传染给他们的子女。Schweitzer等报告31例患乙型肝炎的产妇所生婴儿中HBsAg阳性者17例。这批产妇中,在妊娠早期(1～3个月)患急性乙型肝炎6人,无新生儿肝炎患者;在
In 1970, it was reported that HBsAg was detected in the blood of a small baby without clinical manifestations or with no biochemical changes. Another case of neonatal hepatitis was reported in the same year and HBsAg was detected in both children and their mothers. Kattamic et al. Two newborns with hepatitis were also reported to have HBAg; HBV was later known to be transmitted to their children by pregnant women with HBsAg-positive or asymptomatic HBsAg carriers. Schweitzer et al. Reported 17 HBsAg positive mothers in 31 infants born to hepatitis B virus. Among these mothers, 6 were acute hepatitis B in the first trimester of pregnancy (1 to 3 months) and none had neonatal hepatitis;