免疫抑制剂的疗效,是由多种因素相互利用参与的,细胞毒性药物的原始作用方式是杀死抗元反应性细胞(Antigen—responsive cells)。以往研究中我们已提出测定这些药物的“杀伤”作用最重要的因素有三个;一是靶细胞的增殖能力,二是药物的细胞周期特异性,三是对 T 细胞和 B 细胞的相对选择性。本文介绍用玫瑰花结形成及补体玫瑰花结形成试验方法来测定豚鼠给予免疫抑制剂后 T 淋巴细胞和 B The efficacy of immunosuppressive agents is mediated by the interaction of multiple factors, and the primary way for cytotoxic drugs is to kill Antigen-responsive cells. Previous studies have suggested that there are three important determinants of the “killing” effect of these drugs: one is the proliferation of target cells, and the other is the cell-cycle specificity of the drug. The third is relative to T cells and B cells Selective. This article describes the use of rosette formation and complement rosette formation test method to determine guinea pigs immunosuppressive agents after T lymphocytes and B