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目的:评价新柏氏液基薄层细胞学(TCT)技术联合HPV-DNA检测对宫颈病变的诊断价值。方法:用TCT技术筛查并与病理学诊断相比较,对宫颈炎和宫颈上皮内瘤变(CIN)一级及其以上(≥CIN1)病例各200例进行高危型HPV16/18型荧光定量PCR检测。结果:TCT技术诊断与病理学诊断的符合率达99.5%;宫颈病变≥CIN1组HPV16/18型感染阳性病例69例,阳性率34.5%;宫颈炎对照组HPV16/18型感染阳性病例16例,阳性率8.0%。两组比较差异有统计学意义(P<0.005)。结论:新柏氏液基薄层细胞学检查为一种准确、简便的宫颈病变的细胞学检查方法,结合HPV-DNA检测更不失为一种先进的宫颈上皮内瘤变和宫颈癌的筛查方法。
Objective: To evaluate the diagnostic value of neo-Burman’s liquid-based thin-layer cytology (TCT) combined with HPV-DNA test in diagnosis of cervical lesions. Methods: Screening with TCT and compared with pathological diagnosis, 200 cases of cervicitis and cervical intraepithelial neoplasia (CIN) and above (≥CIN1) cases were screened by high-risk HPV16 / 18 fluorescence quantitative PCR Detection. Results: The coincidence rate of TCT technique diagnosis and pathological diagnosis was 99.5%. The HPV16 / 18 infection positive cases in cervical lesions ≥CIN1 group were 69 cases, the positive rate was 34.5%. The HPV16 / 18 infection positive cases in cervicitis control group were 16 cases, The positive rate of 8.0%. The difference between the two groups was statistically significant (P <0.005). Conclusions: Neo-Parker’s liquid-based thin-layer cytology is an accurate and simple method for cytological examination of cervical lesions. Combined with HPV-DNA detection, it is an advanced screening method for cervical intraepithelial neoplasia and cervical cancer.