论文部分内容阅读
Atriopeptin Ⅲ(APⅢ) and its six analogues were synthesized by solid phase methodrrrrrrrrnand their diuretic and hypotensive activities were determined.Among these analogues,rrrrrrrrnanalogue[D-Ala-5.D-Arg-23]APⅢ was nearly 10 times as potent sa AP Ⅲ in diuretic rrrrrrrrnactivity while its hypotensive activity increased only 50% of that of AP Ⅲ.Analoguerrrrrrrrndes[Ser-15Gly-16Leu-17Gly-18Asn-20Ser-21] AP Ⅲ was 15% as potent as AP Ⅲ in diureticrrrrrrrrnactivity,but it still maintained about 60% of the hypotensive activity of AP Ⅲ.rrrrrrrrnMeanwhile,we tried analogue[D-Ala-5,D-Agr-23]AP Ⅲ for the treatment of hypertensive rrrrrrrrnsyndrome in pregnancy and obtained some good results.
Atriopeptin Ⅲ (APⅢ) and its six analogues were synthesized by solid phase method r r r r r r r nand their diuretic and hypotensive activities were determined. Among these analogues, r r r r r r r nanalogue [D-Ala-5.D-Arg-23] APIII was nearly 10 times as potent sa AP III in diuretic r r r r r r r r nactivity while its hypotensive activity was increased by only 50% of that of AP III. Analogue r r r r r r r ndes [Ser- 15Gly- 16Leu- 17Gly- 18Asn- 20Ser-21] APIII was 15% as potent as APIII in diuretic r r r r r r r nactivity, but it still maintained about 60% of the hypotensive activity of APIII. r r r r r r r nMeanwhile, we tried analogue [D-Ala-5, D-Agr-23] APIII for the treatment of hypertensive r r r r r r r r nsyndrome in pregnancy and obtained some good results.