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目的:探讨Caveolin-1、E-cadherin在肾细胞癌中的表达及其临床意义。方法:采用免疫组织化学EnVision法检测41例肾细胞癌切除标本中Caveolin-1和E-cadherin的表达,并分析表达情况与肿瘤的生物学行为的关系。结果:Caveolin-1在肾细胞癌中的表达阳性率为41.5%,与肿瘤分期、Fuhrman分级及患者年龄呈正相关(P<0.05);E-cadherin表达阳性率为24.4%,低于癌旁肾组织(50%),E-cadherin表达与肿瘤细胞核分级相关(P<0.05),与其他临床病理参数之间无相关性。Caveolin-1和E-cadherin两者之间表达无相关性。结论:Caveolin-1过表达及E-cadherin的异常表达,可能在肾细胞癌的生长、分化中发挥重要作用。
Objective: To investigate the expression of Caveolin-1 and E-cadherin in renal cell carcinoma and its clinical significance. Methods: The expressions of Caveolin-1 and E-cadherin in 41 specimens of renal cell carcinoma were detected by immunohistochemistry EnVision. The relationship between the expression of Caveolin-1 and E-cadherin and the biological behavior of the tumor was analyzed. Results: The positive rate of Caveolin-1 in renal cell carcinoma was 41.5%, which was positively correlated with tumor stage, Fuhrman grade and age of patients (P <0.05). The positive rate of E-cadherin was 24.4% The expression of E-cadherin was correlated with the nuclear grade of tumor (P <0.05), but not with other clinicopathological parameters. There was no correlation between Caveolin-1 and E-cadherin expression. Conclusion: Overexpression of Caveolin-1 and abnormal expression of E-cadherin may play an important role in the growth and differentiation of renal cell carcinoma.