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四川大学华西医院于2007年3月对一位65岁高龄的2型糖尿病患者成功施行了胰肾联合移植手术。患者为男性,患2型糖尿病史15年,合并肾功能衰竭5年,并出现糖尿病眼底病变、周围神经损害等症状。手术将供肾移植于左侧髂窝,供胰移植于右侧髂窝,胰腺外分泌引流采用经肠道、内分泌回流采用经体循环途径的术式。术后第1dC-肽即达正常水平,第4d血肌酐恢复正常,第11d血尿素氮恢复正常;血糖逐渐趋于稳定,第16d完全停用胰岛素。术后3周OGTT结果显示移植胰腺功能正常。无任何并发症。术后随访6月余,血糖稳定,完全停用胰岛素,肾功能正常,视力也有一定程度的恢复。
West China Hospital of Sichuan University in March 2007 successfully performed a pancreas-kidney transplantation on a 65-year-old type 2 diabetic patient. The patient was male, had a history of type 2 diabetes mellitus for 15 years, had renal failure for 5 years, and had diabetic retinopathy and peripheral nerve damage. Surgery will be for renal transplantation in the left iliac fossa, for pancreas transplantation in the right iliac fossa, pancreatic exocrine drainage by the intestine, endocrine reflux by the systemic circulation approach. The level of C-peptide reached the normal level on the first day after operation, serum creatinine returned to normal on the 4th day, and the level of blood urea nitrogen returned to normal on the 11th day. The blood glucose gradually stabilized and the insulin was stopped completely on the 16th day. OGTT results 3 weeks after transplantation showed normal function of pancreas. No complications. Follow-up more than 6 months after surgery, blood glucose was stable, completely disable insulin, normal renal function, visual acuity also have a certain degree of recovery.