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目的探讨软组织血管纤维瘤(AFST)的临床病理学特征及鉴别诊断要点。方法对1例AFST进行组织形态学及免疫组化分析,并复习相关文献。结果患者为31岁女性。B超发现右大腿肌层内直径5.5 cm囊性、界清肿块。组织学为散在分布温和的圆形、卵圆形纤维母细胞样肿瘤细胞,背景为明显分支纤细血管网,间质不同程度胶原化及黏液变性;肿瘤细胞vimentin、EMA、ER、CD68和CD163(+),S-100、GFAP、NF、catenin-β、SMA、CD34、ERG和LCA均(-),Ki-67阳性指数3%。术后随访12个月,无复发及转移。结论 AFST是新近报道的少见的良性软组织纤维血管性肿瘤,根据组织病理学及免疫组化特征可确诊。临床工作中注意不要误诊为低度恶性软组织肉瘤。
Objective To investigate the clinicopathological characteristics and differential diagnosis of soft tissue vascular fibroma (AFST). Methods One case of AFST was histomorphologically and immunohistochemically analyzed, and relevant literature was reviewed. Results The patient was 31 years old. B-found right thigh muscle 5.5 cm cystic inner diameter, clear mass. Histomorphology of the sporadic distribution of mild round, oval fibroblastoid tumor cells, the background of the obvious branch slender vascular network, interstitial collagen and mucinous degeneration to varying degrees; tumor cells vimentin, EMA, ER, CD68 and CD163 ( +), S-100, GFAP, NF, catenin-β, SMA, CD34, ERG and LCA (-), Ki-67 positive index of 3%. All cases were followed up for 12 months without recurrence and metastasis. Conclusion AFST is a newly reported rare benign soft tissue fibrovascular tumor that can be diagnosed based on histopathology and immunohistochemical features. Do not misdiagnose clinically as low grade soft tissue sarcoma.