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观察阿苯达唑和吡喹酮治疗沙鼠泡球蚴的病理形态学改变、肝脏组织内泡球蚴形态变化和泡球蚴囊周组织反应。为观察疗效，将肝脏泡球蚴分为Ⅰ级：衰退性囊泡、Ⅱ级：静止性囊泡和Ⅲ级：增殖性囊泡。结果显示：阿苯达唑剂量较大组（５０ｍｇ／ｋｇ·ｄ）Ⅰ级囊率最高（Ｐ＜０．０５），其次为吡喹酮两组。早期治疗组比晚期治疗组Ⅰ级囊率为高。泡球蚴囊周淋巴细胞数以阿苯达唑治疗组为高（１０６．９±３４．３—３００．１±５９．５）（Ｐ＜０．０００１）。联合用药组无明显提高疗效作用。
To observe the pathological changes of albuterol and praziquantel in the treatment of Echinococcus granulosus, morphological changes of Eubacteria in the liver tissue and cystic tissue reaction of the cysticercosis. In order to observe the curative effect, the liver epidermidis were divided into Ⅰ grade: decidual vesicles, Ⅱ grade: static vesicles and Ⅲ grade: proliferative vesicles. The results showed that the first grade capsules of albendazole at the dose of 50 mg / kg · d were the highest (P <0.05), followed by praziquantel. Early treatment group than the late treatment group Ⅰ grade capsule rate is high. The number of lymphocytes in cysticercus was higher in the albendazole group (106.9 ± 34.3-300.1 ± 59.5) (P <0.0001). Combination therapy group did not significantly improve the therapeutic effect.