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目的:评估中老年女性血清铁蛋白(SF)水平与年龄和体质指数(BMI)之间的关系。方法:选自中国4046名健康女性进行横断面研究,受试者年龄均在45-70岁并签署了知情同意书。所有受试者血清铁蛋白水平采用放射免疫分析法测定。采用Spearman秩相关检验分析血清铁蛋白与各指标之间的相关性。不同组别SF差异的显著性用Kruskal-Wallis秩和检验来比较。结果:Spearman相关性分析显示血清铁蛋白与年龄(r=0.425;p<0.05)和BMI(r=0.238;p<0.05)均呈正相关。Kruskal-Wallis秩和检验显示不同年龄组和不同BMI组的血清铁蛋白水平均有显著性差异(p<0.05)。65-70岁人群的血清铁蛋白平均水平比45-50岁人群高出近两倍。并且肥胖人群中血清铁蛋白水平要远远高于偏瘦人群。结论:中老年女性铁储存的增加与年龄的增长和体质指数的增加呈现正相关关系。
Objective: To evaluate the relationship between serum ferritin (SF) level and age and body mass index (BMI) in middle-aged and elderly women. METHODS: A cross-sectional study of 4046 healthy women from China was conducted. Subjects aged 45-70 years old signed informed consent forms. Serum ferritin levels were measured by radioimmunoassay in all subjects. Spearman rank correlation test was used to analyze the correlation between serum ferritin and each index. The significance of SF differences among different groups was compared using the Kruskal-Wallis rank sum test. RESULTS: Spearman correlation analysis showed that serum ferritin was positively correlated with age (r = 0.425; p <0.05) and BMI (r = 0.238; p <0.05). Kruskal-Wallis rank sum test showed that serum ferritin levels in different age groups and different BMI groups were significantly different (p <0.05). The average level of serum ferritin in people aged 65-70 is nearly double that of people in 45-50 years old. And the level of serum ferritin in obese people is much higher than the lean people. Conclusion: The increase of iron in middle-aged and elderly women shows a positive correlation with the increase of age and body mass index.