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采用免疫组化Ｓ－Ｐ法对７７例涎腺良性多形性腺瘤与１１例恶性多形性腺瘤的ｒａｓ－Ｐ２１表达状况进行了观察．结果：良性多形性腺瘤ｒａｓ－Ｐ２１表达阳性率为１９４８％（１５／７７），恶性者为６３６３％（７／１１）．两者经χ２检验，阳性率差异有非常显著意义（Ｐ＜０００５）．提示：恶性涎腺多形性腺瘤的发生，可能与ｒａｓ－Ｐ２１激活有关．可用于临床诊断与估计预后的参考．而良性多形性腺瘤的阳性表达是否可作为其复发与恶变的表示，尚待进一步研究．
The expression of ras-P21 in 77 salivary gland benign pleomorphic adenomas and 11 cases of malignant pleomorphic adenomas was observed by immunohistochemical S-P method. Results: The positive rate of ras-P21 was 1948% (15/77) in benign pleomorphic adenoma and 6363% (7/11) in malignant pleomorphic adenoma. The two by χ2 test, the positive rate difference was significant (P <0005). Tip: The occurrence of malignant salivary gland adenoma may be related to ras-P21 activation. Can be used for clinical diagnosis and prognosis of the reference. The positive expression of benign pleomorphic adenoma can be used as a sign of recurrence and malignant transformation, yet to be further studied.