论文部分内容阅读
综合过去报道,肾疾病使用免疫抑制剂多指抗类固醇激素的肾病综合征,因为多数肾病综合征首选类固醇激素治疗。据酒井等报道,成人原发性肾病综合征类固醇激素治疗的有效率为42%,余下58%即为抗类固醇激素的肾病综合征。据报告,这些病例如与免疫抑制剂并用,约20%的患者有效。1.微小变化型肾病综合征本病对类固醇激素反应良好,缓解率几乎100%,但复发率约60%,即成为反复再发型肾病综合征。对此类病例并用免疫抑制剂,能预防复发和延长缓解期。过去使用硫唑嘌呤50～100mg/日和环磷酰胺50～100mg/日,目前,布雷青霉素和环孢素A的疗效正在验证之中。
Comprehensive past reports, kidney disease using immunosuppressive agents more finger anti-steroid hormone nephrotic syndrome, because most of the nephrotic syndrome preferred steroid treatment. According to reports such as Sakai, adult primary nephrotic syndrome steroid treatment efficiency was 42%, the remaining 58% is anti-steroid hormone nephrotic syndrome. It is reported that these cases, for example, are combined with immunosuppressive agents, and about 20% of patients are effective. 1. Small changes in nephrotic syndrome The disease response to steroid hormone good response rate was almost 100%, but the recurrence rate of about 60%, which became repeatedly recurrent nephrotic syndrome. In such cases with immunosuppressive agents, can prevent recurrence and prolong remission. In the past the use of azathioprine 50 ~ 100mg / day and cyclophosphamide 50 ~ 100mg / day, at present, the efficacy of debrint penicillin and cyclosporine A is being verified.