取代苯酚的烷基醚是一类重要的有机中间体,常用于染料、农用杀虫剂及除草剂的合成。酚钠与卤代烷反应的Williamson法虽是制备烷基芳醚的经典方法,但操作手续繁,反应条件苛刻,应用非质子溶剂如DMSO虽可缓和反应条件,但溶剂价昂,回收困难。最近有用多磷酸(PPA)作缩合剂由苯酚与甲醇或乙醇直接反应成醚的报导,但得率很低。相转移催化反应是近十年来发展起来的有机合成新方法,常用于有机化合物的G-, Alkyl ethers substituted phenol is an important class of organic intermediates, commonly used in the synthesis of dyes, agricultural pesticides and herbicides. The Williamson method for the reaction of sodium phenolate with alkyl halides is a classic method for preparing alkyl aryl ethers. However, the procedure is complicated and the reaction conditions are harsh. The application of aprotic solvents such as DMSO can ease the reaction conditions, but the solvent is expensive and the recovery is difficult. The recent use of polyphosphoric acid (PPA) as a condensing agent from phenol and methanol or ethanol directly into ether reported, but the yield is very low. Phase transfer catalysis is a new organic synthesis method developed in recent ten years, commonly used in organic compounds G-,