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目的:探讨多环芳烃(PAHs)在人类直肠癌发生过程中的作用。方法:直肠癌组织、癌旁组织和非直肠癌患者的直肠组织中的PAHs分别经超声提取,固相萃取净化和高效液相色谱荧光分析。结果:3组标本中共检出4种PAHs,分别是菲、芘、2-甲基蒽和苯并(a)芘。其中芘、2-甲基蒽和苯并(a)芘在直肠癌组织和癌旁组织中的含量均高于非直肠癌患者的直肠组织,差异有统计学意义,P<0.05;菲在3组标本中的含量差异无统计学意义,P>0.05;4种PAHs在直肠癌组织与癌旁组织中的含量差异均无统计学意义,P>0.05。结论:人类直肠组织中存在PAHs;人类直肠组织中PAHs的含量与直肠癌的发生有一定的相关性。
Objective: To investigate the role of polycyclic aromatic hydrocarbons (PAHs) in the development of human rectal cancer. METHODS: PAHs in rectal tissue of rectal cancer tissues, paracancerous tissues and rectal cancer patients were extracted by ultrasound, purified by SPE and analyzed by high performance liquid chromatography (HPLC). Results: Four kinds of PAHs were detected in three groups, namely phenanthrene, pyrene, 2-methylanthracene and benzo (a) pyrene. The contents of pyrene, 2-methylanthracene and benzo (a) pyrene in rectal cancer tissue and adjacent tissues were higher than those in rectal cancer patients, the difference was statistically significant, P <0.05; The contents of four kinds of PAHs in rectal cancer tissues and adjacent tissues showed no significant difference (P> 0.05). Conclusion: There are PAHs in human rectum. The content of PAHs in human rectum has a certain correlation with the occurrence of rectal cancer.