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目的探讨原发性双侧乳腺癌(BPBC)的临床病理特征。方法回顾性分析21例BPBC患者(A组)的临床病理资料,并与同期50例原发性单侧乳腺癌(UPBC)患者(B组)资料作比较。结果 A组患者家族史阳性率高于B组(14.3%vs.2.0%)(P<0.05)。A组乳腺癌组织中人表皮生长因子受体2(HER-2)阳性表达率较B组高(33.3%vs.12.0%)(P<0.05),而雌激素受体和孕激素受体的阳性表达率较B组稍低(P>0.05)。结论 HER-2可能与BPBC发病有关。
Objective To investigate the clinicopathological features of primary bilateral breast cancer (BPBC). Methods The clinicopathological data of 21 patients with BPBC (group A) were retrospectively analyzed and compared with the data of 50 patients with primary unilateral breast cancer (group B) in the same period. Results The positive rate of family history in group A was higher than that in group B (14.3% vs.2.0%) (P <0.05). The positive rate of HER-2 expression in group A was significantly higher than that in group B (33.3% vs. 12.0%, P <0.05), while the expression of estrogen and progesterone receptor The positive expression rate was lower than that in group B (P> 0.05). Conclusion HER-2 may be related to the pathogenesis of BPBC.