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目的：观察MRI在脑桥中央髓鞘溶解症（CPM）早期诊断中的作用。方法：报告4例CPM，对其MRI、临床诊断、治疗、预后及发病机制进行回顾和分析。结果：4例CPM均有慢性消耗疾病、电解质紊乱或营养不良的基础；具有闭锁综合征表现，MRI示脑桥基底部对称分布的T_1长T_2信号的脱髓鞘改变仅1例，桥脑与脑其他部位同时存在脱髓鞘改变3例。经缓慢矫正电解质紊乱，给激素、脱水剂等治疗，3例好转，1例死亡。结论：CPM好发于有电解质紊乱或（和）营养不良的疾病，矫正电解质紊乱宜缓慢。脑MRI对本病早期诊断是最有效的检查手段，病因和发病机制未阐明。
Objective: To observe the role of MRI in the early diagnosis of central pontine myelinolysis (CPM). Methods: Four cases of CPM were reported and their MRI, clinical diagnosis, treatment, prognosis and pathogenesis were reviewed and analyzed. Results: All 4 CPM patients had the basis of chronic consumptive disease, electrolyte imbalance or malnutrition. With the manifestation of atresia syndrome, MRI showed that there was only one demyelination of T 1 long T 2 signal symmetrically distributed at the basal part of pons. Other parts of the same time there are three cases of demyelination. Electrolyte disorder was corrected slowly, hormones and dehydrating agents were treated, 3 cases improved and 1 case died. CONCLUSIONS: CPM develops in disorders with electrolyte imbalance and / or malnutrition, and corrective electrolyte disturbances should be slow. Brain MRI early diagnosis of the disease is the most effective means of examination, etiology and pathogenesis is not elucidated.