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目的:了解降纤酶与其他药物治疗急性脑梗死(acutecerebralinfarc-tion,ACI)疗效的差异。方法:应用Meta分析对10项研究降纤酶与其他药物治疗ACI的效果进行同质性检验和合并效应量的估计。结果:①同质性检验:χ2=6.8452,自由度为9,P>0.05。②合并效应量的估计:OR合并=3.2353,OR合并95%可信区间为2.21～4.74。OR合并的检验:χ2=36.2,P<0.001。结论:降纤酶治疗ACI的疗效显著优于目前常用药物,其在适应证、治疗剂量、给药方法及用药时限等方面与临床疗效的关系有待进一步研究。
Objective: To understand the difference between curative effect of defibrase and other drugs in the treatment of acute cerebral infarction (ACI). Methods Meta-analysis was used to evaluate the effect of 10 defibrase and other drugs on the treatment of ACI. Results: ① homogeneity test: χ2 = 6.8452, degree of freedom 9, P> 0.05. ② The estimated effect of combined effects: OR combined = 3.2353, OR 95% confidence interval was 2.21 ~ 4.74. OR combined test: χ2 = 36.2, P <0.001. Conclusion: The therapeutic effect of defibrase on ACI is significantly better than that of currently used drugs. The relationship between defibrase and ACI has to be further studied in terms of indications, therapeutic doses, administration methods and time limits of treatment.