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探讨与评价抗肿瘤药物肝毒性,为肝功能受损患者的抗肿瘤药物剂量调整提供建议。通过检索和分析国内外相关研究文献,并对其进行综合和归纳,发现抗肿瘤药物的肝毒性可有多种表现,并可出现肝静脉阻塞病等严重不良反应,造成患者死亡。依据现有文献,多西他赛、多柔比星等药物可根据肝功能检查结果进行合理剂量调整。临床应关注抗肿瘤药物肝毒性,依据肝功能合理调整抗肿瘤药物剂量,但目前需进一步研究,建立相关指南,保证化疗安全有效的进行。
To discuss and evaluate the hepatotoxicity of anticancer drugs and to provide suggestions for the adjustment of anticancer drug dose in patients with impaired liver function. Through the search and analysis of relevant research literature at home and abroad, and the synthesis and induction of them, it is found that the hepatotoxicity of antineoplastic drugs can have various manifestations, and serious adverse reactions such as hepatic vein occlusion may occur, resulting in the death of patients. According to the existing literature, docetaxel, doxorubicin and other drugs can be adjusted according to the liver function test results. Clinic should pay attention to the hepatotoxicity of antineoplastic drugs and adjust the dose of antineoplastic drugs according to liver function reasonably. However, further research is needed to establish relevant guidelines to ensure the safe and effective chemotherapy.