先兆子痫是炎症介导的妊娠期高血压疾病,是心血管病风险增加的早期指标,但这种关联的基本机制目前还不清楚。该研究纳入有严重早发型先兆子痫病史的44名妇女,在其产后1.5~3.5年测定其循环炎症标志物水平,观察系统性急性期动态炎症反应,同时纳入29名正常妊娠妇女作为对照组。使用的模型为体内季节性流感疫苗接种和体外用T细胞刺激物及toll样受体4配体脂多糖进行全血培养。观察指标为 Preeclampsia is an inflammation-mediated hypertensive disorder of pregnancy and is an early indicator of an increased risk of cardiovascular disease, but the underlying mechanisms of this association are not yet clear. Forty-four women with a history of severe premature eclampsia were enrolled in this study. Levels of circulating inflammatory markers were measured 1.5 to 3.5 years postpartum and dynamic systemic inflammatory responses were observed. A total of 29 normal pregnant women were included as controls . The models used were whole-blood cultures for in vivo seasonal influenza vaccination and in vitro use of T cell stimulators and toll-like receptor 4 ligand lipopolysaccharide. The observation index is