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目的：探讨白血病 Ｍ Ｄ Ｒ１表达的意义，建立 Ｍ Ｄ Ｒ１检测的简便快速方法。方法：用流式细胞术和经 Ｆ Ｉ Ｔ Ｃ 标记 Ｍ Ｄ Ｒ１单克隆抗体检测白血病外周血有核细胞 Ｍ Ｄ Ｒ１的表达。结果：２４例急性白血病 Ｍ Ｄ Ｒ１表达为８９８±７４７，３例慢性白血病 Ｍ Ｄ Ｒ１表达为３６０±１３０，两组间差异有高度显著性（ Ｐ＜ ００１）。在急性非淋巴细胞白血病各亚型中， Ｍ ３的 Ｍ Ｄ Ｒ１表达最低，依次增高为 Ｍ ２、 Ｍ ４ ，３组间差异显著（ Ｐ＜ ００１）。结论：本方法简便、快速，可作为白血病临床治疗的评价指标。
Objective: To explore the significance of MDR1 expression in leukemia and establish a simple and rapid method for MRD1 detection. METHODS: The expression of MDR1 in peripheral blood leukemic cells was detected by flow cytometry and FICC-labeled MDR1 monoclonal antibody. Results: 24 cases of acute leukemia M D R1 expression was 8 98 7 47, 3 cases of chronic leukemia M D R1 expression was 3 60 1 30, the difference between the two groups was highly significant (P < 0 01 ). In all subtypes of acute non-lymphocytic leukemia, the MRD1 expression of M3 was the lowest, which was increased to M2 and M4 in turn, and the difference among the three groups was significant (P<0.01). Conclusion: This method is simple, rapid and can be used as an evaluation index of clinical treatment of leukemia.