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目的观察女性血小板减少性紫癜与自身免疫状态关系,自身免疫状态的观察指标为血清免疫球蛋白、抗核抗体、抗可提取性核抗原谱、补体C3/C4。方法选取濮阳市安阳地区医院近0.5a来因外周血血小板减少入住的女性患者,骨髓穿刺检查排除其他疾病,共16例,通过免疫比浊法测定血清球蛋白及补体含量,免疫印迹法检测抗可提取性核抗原谱,间接免疫荧光法检测抗核抗体。结果血小板减少患者抗可提取性核抗原阳性率高,抗核抗体阳性率明显高于正常人,且免疫球蛋白与补体C3/C4呈负相关。结论对女性血小板减少性紫癜患者行自身免疫状态检查是有必要的。
Objective To observe the relationship between thrombocytopenic purpura and autoimmune status in women and to observe the status of autoimmune diseases such as serum immunoglobulin, antinuclear antibody, anti - extractable nuclear antigen spectrum, complement C3 / C4. Methods A total of 16 female patients with peripheral blood thrombocytopenia admitted to Anyang hospital in Puyang City during the past 0.5 years were excluded. A total of 16 patients were excluded from the bone marrow biopsy. Serum globulin and complement levels were measured by immunoturbidimetric assay. Extractable nuclear antigen spectrum, indirect immunofluorescence detection of anti-nuclear antibodies. Results Thrombocytopenia patients with anti-extractable nuclear antigen positive rate, anti-nuclear antibody positive rate was significantly higher than normal, and immunoglobulin and complement C3 / C4 was negatively correlated. Conclusions Female idiopathic thrombocytopenic purpura patients with autoimmune state examination is necessary.