POEMS综合征又名Crow-Fukase综合征、Takatsuki综合征、多发性神经病-脏器肿大-内分泌病-M蛋白-皮肤综合征。以多发性神经病变(P)、内脏肿大(O)、内分泌异常(E)、M蛋白血症或浆细胞瘤(M)及皮肤改变(S)为临床特征。鉴于国内报道甚少,现将我院所见1例报告如下。病例报告患者女,32岁。两年来逐渐发生四肢麻木与乏力、畏冷、食少、心慌、气短,腹胀、闭经 POEMS syndrome, also known as Crow-Fukase syndrome, Takatsuki syndrome, polyneuropathy - organ enlargement - endocrine disease - M protein - skin syndrome. To multiple neuropathy (P), visceral enlargement (O), endocrine abnormalities (E), M proteinuria or plasmacytoma (M) and skin changes (S) as the clinical features. In view of very few domestic reports, now I see a hospital report as follows. Case report Female patient, 32 years old. Over the past two years numbness and fatigue gradually limbs, chills, food less, palpitation, shortness of breath, bloating, amenorrhea