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诺氟沙星用药后的不良反应屡见报道，但上述报道的不良反应均为临床症状。为了探讨引起临床不良反应的主要原因，以寻求解决方法。本实验用不同剂量诺氟沙星灌喂小鼠，分批将实验动物处死，组织学观察实验动物的主要器官病理改变。实验结果提示，用药ｌ周后即出现组织器官损害。同时发现用药后损害最严重的是心肌，其次为肺、肝和肾。提示临床用药时，注意保护上述器官。
Adverse reactions after norfloxacin were frequently reported, but the adverse reactions reported above were all clinical symptoms. In order to explore the main causes of clinical adverse reactions in order to find a solution. In this experiment, mice were fed with different doses of norfloxacin, the experimental animals were sacrificed in batches, and histopathological changes of the main organs of the experimental animals were observed histologically. Experimental results suggest that l weeks after treatment of tissue and organ damage. Also found that the most serious damage after treatment is myocardial, followed by lung, liver and kidney. Prompt clinical medication, pay attention to protect the above organs.