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一前言甲基多环芳烃是多环芳烃的重要类型,在香烟的烟中、汽车的排气中、煤气和煤燃烧的排出物中都有足够量的甲基取代多环芳烃,绝大多数的甲基取代物和其母体多环芳烃之间致癌性差别不大,但有些甲基取代多环芳烃却在致癌性方面明显地不同于其母体多环烃的致癌性。尤其是四个环分子左右的分子表现得十分突出。例如(艹屈),其分子结构式如图1所示它表现较小的致癌活性,其甲基衍生物MC,在1,2,3,4,7,8,9,10,位置上的甲基取代(艹屈)仅表现较小的致癌活性,而6位(或12位)仅表现稍强的活性,但是5(或11)位的甲基取代(艹屈)却表现与苯并(a)芘相当的致癌活性.又例如苯并(a)蒽其分子结构式
A preface Methyl polycyclic aromatic hydrocarbons are important types of polycyclic aromatic hydrocarbons, cigarette smoke, car exhaust, gas and coal combustion emissions have a sufficient amount of methyl-substituted PAHs, the vast majority Of the methyl substituents and their parent PAHs are not much different from each other in their carcinogenicity, some methyl-substituted PAHs differ markedly in carcinogenicity from the carcinogenicity of their parent polycyclic hydrocarbons. In particular, four ring molecules around the performance of the very prominent. For example, it has the molecular structure shown in Figure 1, which shows less oncogenic activity. Its methyl derivative MC, at positions 1, 2, 3, 4, 7, 8, 9, Substitutive substitution showed only less oncogenic activity, while 6 (or 12) showed only slightly more potent activity, but the 5 (or 11) a) pyrene considerable oncogenic activity. Another example benzo (a) anthracene its molecular structure