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目的了解高血糖对2型糖尿病患者胰岛β细胞功能的影响。方法采用葡萄糖耐量试验(OGTT),观察17例2型糖尿病(T2dM)患者胰岛β细胞在前后不同血糖状态下的功能变化。结果血糖控制后,患者体内胰岛素及C肽释放水平均显著升高(P<0.05)。结论高血糖可抑制2型糖尿病患者胰岛β细胞的功能,及早有效的控制患者血糖水平可以保护胰岛β细胞功能。
Objective To investigate the effect of hyperglycemia on pancreatic β-cell function in type 2 diabetic patients. Methods The glucose tolerance test (OGTT) was used to observe the functional changes of islet β cells in 17 patients with type 2 diabetes (T2dM) under different blood glucose levels. Results After blood glucose control, the levels of insulin and C-peptide release in patients were significantly increased (P <0.05). Conclusion Hyperglycemia can inhibit the function of pancreatic β-cells in type 2 diabetic patients, and early and effective control of blood glucose levels can protect the islet β-cell function.