Objective: To study the molecular mechanism of Mori Cortex - Lycii Cortex for infantile pneumonia based on network pharmacology. Methods: TCMSP and BATMAN-TCM online prediction database were used to screen and collect the active ingredients and targets of Mori Cortex - Lycii Cortex with oral bioavailability (OB) and drug-like(DL). Predictive analysis of disease targets was conducted through PubMed, GeneCards and DrugBank databases. The component-target regulation network was constructed by using Cytoscape 3.7.2 software, and the network topology of the core target was analyzed. Finally, the Bioconductor platform and R language were used for GO function analysis and KEGG pathway enrichment analysis, and the target-key pathway network diagram was constructed. Results: A total of 43 active components, including quercetin, kaempferol, acacetin, and beta-sitosterol, were identified with 242 potential targets. There were 3271 pneumonia targets in children, among which the key targets were IL-6, AKT1, MAPK8, etc. There were 31 common targets of MMP9, TNF, AKT1 and so on. GO biological processes include the response to lipopolysaccharides, molecule of bacterial origin, metal ions, regulation of apoptotic signaling pathway, and T cell activation. The KEGG signaling pathways involved mainly include TNF, PI3K/AKT and MAPK signaling pathway.Conclusion: Mori Cortex - Lycii Cortex for quercetin, kaempferol, beta-sitosterol and acacetin element composition such as possible through the AKT1, MAPK8, IL-6 and MMP9 targets in the role of such as TNF, PI3K/AKT, MAPK signal pathways and so on several signal transduction pathways that play to the role of the treatment of children pneumonia, the results can be for the further study of Mori Cortex - Lycii Cortex for mechanisms to provide the reference for the treatment of pneumonia in children.