心脏重构是各类心血管疾病的重要进程之一，包括心肌梗死、瓣膜疾病、心肌炎、扩张型心肌病、心房颤动和心力衰竭等。多项研究发现，微 RNA（ miRNA）与此过程息息相关，并且在体内和体外实验模型中都证实了 miRNA 广泛地参与此进程。临床上，miRNA 已作为潜在的诊断指标和治疗靶点被重视。该文就近年的热点及被重点研究的几种 miRNA 进行综述。“,”Cardiac remodeling is the key process in cardiovascular diseases including myocardial infarc-tion,valvular disease,myocarditis,dilated cardiomyopathy,atrial fibrillation and heart failure.Both in vitro and vivo models have proved that microRNAs play an important role in a wide range of processes.Clinically, miRNAs have been attached much attention as the potential diagnostic biomarkers and novel therapeutic tar-get recently.Here is to make a review of the focal points and mostly studied miRNA in the recent years.