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本文观察11例急性心肌梗塞并发充血性心力衰竭的病人口服盐酸哌唑嗪的血液动力学的效应。结果心脏指数由2.38±0.42L/min/M~2增加到应用哌唑嗪半小时后的2.8±0.6L/min/M~2(P<0.05)。最大的改善出现在服药1小时后,且6小时后的数值仍有统计学意义,12小时达到对照数值。右心房压力有明显持续性地下降,由12.5±4.6mmHg下降到服药30分钟后的8.8±3.9mmHg(P<0.05),3小时后达到最高效应,12小时后仍有效应。肺毛细血管压在服药前为29.8±6.8mmHg,服药3小时呈现明显的下降为15.7±7.2mmHg(P<0.001),并持续到6小时,而12小时后又回升。动脉压由114±13.6mmHg,服药1小时后下降到96.8±13.6mmHg
This article observed 11 patients with acute myocardial infarction congestive heart failure patients oral administration of prazosin hydrochloride hemodynamic effects. Results The cardiac index increased from 2.38 ± 0.42 L / min / M ~ 2 to 2.8 ± 0.6 L / min / M ~ 2 after prazosin administration for half an hour (P <0.05). The greatest improvement occurred 1 hour after taking the medication, and after 6 hours the values remained statistically significant, reaching control values 12 hours later. The right atrial pressure decreased significantly from 12.5 ± 4.6 mmHg to 8.8 ± 3.9 mmHg after 30 minutes (P <0.05), reaching the highest level after 3 hours and still reaching the level after 12 hours. Pulmonary capillary pressure was 29.8 ± 6.8 mmHg before taking the drug and showed a significant drop of 15.7 ± 7.2 mmHg (P <0.001) 3 hours after taking the drug, which lasted for 6 hours and rose again after 12 hours. Arterial pressure by 114 ± 13.6mmHg, medication dropped to 96.8 ± 13.6mmHg after 1 hour