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本文报道自1958年至1988年底于中国医学科学院肿瘤医院治疗的有完整临床及病理资料的10例子宫内膜间质肉瘤。参照组织学分类标准,10例均属于淋巴管内间质异位症(低度恶性子宫内膜间质肉瘤)。发病年龄平均为40.5岁。临床分期为Ⅰ期8例,Ⅱ期1例,Ⅲ期1例,其中Ⅰ期4例,Ⅱ期1例于术中发现肿瘤已播散至子宫以外。10例中8例行全子宫及救附件切除术,1例行全子宫单侧附件切除术,1例于外院手术仅行子宫次全切除术。术前辅以腔内治疗者2例,术后盆腔体外放疗6例,均达放射治疗剂量,术后化疗2例。10例中有2例复发,其中1例治疗后13年复发,经化疗后稳定,于复发后2年仍存活。1例于术后4年复发,经放射治疗后稳定,复发后6年仍存活。其中5例随访达5年以上,其5年及10年存活率均达100％。
This article reports from the end of 1958 to the end of 1988 at the Cancer Hospital of Chinese Academy of Medical Sciences treatment of complete clinical and pathological data of 10 cases of endometrial stromal sarcoma. According to histological classification criteria, 10 cases were all lymphatic endometriosis (low grade endometrial stromal sarcoma). The average age of onset was 40.5 years old. The clinical stage was stage Ⅰ in 8 cases, stage Ⅱ in 1 case and stage Ⅲ in 1 case, of which stage Ⅰ in 4 cases and stage Ⅱ in 1 case found that the tumor had been dissected outside the uterus. In 10 cases, 8 cases underwent hysterectomy and salvage, 1 case had uterine unilateral accessory resection, and 1 case received hysterectomy only under external hospital. Preoperative with endovascular treatment in 2 cases, postoperative pelvic external beam radiotherapy in 6 cases, reaching the radiation dose, postoperative chemotherapy in 2 cases. Two of the 10 patients relapsed, of which 1 had relapsed 13 years after treatment, stabilized after chemotherapy, and survived 2 years after relapse. One patient relapsed 4 years after operation and was stable after radiotherapy and survived 6 years after the recurrence. Among them, 5 cases were followed up for more than 5 years, and their 5-year and 10-year survival rates reached 100%.