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目的:研究纤维连接蛋白在足月分娩预测中的价值。方法:选取2015年3月至2016年9月佛山市南海区第五人民医院收治的孕37~41周孕妇126例为研究对象,均行Bishop宫颈成熟度评分和宫颈分泌物纤维连接蛋白(fFN)检测,以fFN≥50 ng·mL~(-1)作为阳性值将其分为fFN阳性组(n=65)和fFN阴性组(n=61),比较两组宫颈Bishop评分、分娩发动时间及阴道自然分娩时间,同时对比两组使用宫颈扩张球囊促进宫颈成熟+缩宫素点滴引产效率及分娩方式。结果:fFN阳性组宫颈Bishop评分较fFN阴性组高,分娩发动时间(18.17±1.43)h、阴道自然分娩时间(49.14±1.20)min较fFN阴性组短;fFN阳性组应用宫颈扩张球囊促进宫颈成熟+缩宫素点滴引产有效率86.15%、经阴道分娩率67.69%明显高于fFN阴性组54.10%、22.95%,差异具有统计学意义(P<0.05)。结论:fFN预测足月分娩中具有一定临床价值,其宫颈Bishop评分、促宫颈成熟有效率及阴道分娩率高于fFN阴性患者。
Objective: To investigate the value of fibronectin in predicting full-term labor. Methods: From March 2015 to September 2016, 126 pregnant women of 37-41 weeks of gestation from the Fifth People’s Hospital of Nanhai District of Foshan City were enrolled in this study. The Bishop cervical maturity score and cervical fission fibronectin (fFN (N = 65) and fFN negative group (n = 61) with fFN≥50 ng · mL -1 as the positive value. The Bishop score of cervix and the onset time of labor were compared And spontaneous vaginal delivery time, while comparing the use of two groups of cervical dilation balloon to promote cervical ripening + oxytocin drip induction of labor efficiency and mode of delivery. Results: The Bishop score of fFN-positive group was significantly higher than that of fFN-negative group (18.17 ± 1.43 h), spontaneous vaginal delivery time (49.14 ± 1.20) min was shorter than that of fFN-negative group Mature + oxytocin drip induction of labor was 86.15%, vaginal delivery rate of 67.69% was significantly higher than fFN negative group 54.10%, 22.95%, the difference was statistically significant (P <0.05). Conclusion: fFN has a certain clinical value in predicting full-term delivery. The cervical Bishop score, cervical ripening efficiency and vaginal delivery rate are higher than fFN negative patients.