Thickness deviation of hot strip rolling needs to be strictly controlled in the computer system. An adaptive threading technique was researched, in which the measured data from threaded stands were used to predict thickness and material hardness errors, to modify the setup for the remaining unthreaded stands. After the adaptive threading model was used online on the hot strip mill of the Panzhihua Iron and Steel Group Co Ltd, the thickness deviation was decreased obviously. The hit rate of thickness control of different steel grades increases. Thickness deviation of hot strip rolling needs to be strictly controlled in the computer system. An adaptive threading technique was researched, in which the the measured data from threaded stands were used to predict thickness and material hardness errors, to modify the setup for the remaining unthreaded stands . After the adaptive threading model was used online on the hot strip mill of the Panzhihua Iron and Steel Group Co Ltd, the thickness deviation was decreased obviously. The hit rate of thickness control of different steel grades increases.