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目的：观察参麦注射液对造血系统恶性肿瘤化疗期间心脏的保护作用。方法：对２５ 例造血系统恶性肿瘤合并心血管病的患者随机分为３组：参麦注射液组（１０例）化疗前３小时开始静滴参麦注射液４０～６０ ｍ ｌ，１ 次／ｄ，共用１０ 日；设对照组（１０ 例）；自身对照组（５例），第１ 次化疗不用参麦注射液，第２ 次加用参麦注射液。结果：心功能方面，参麦组与对照组，及自身对照组化疗前后比较无显著差异（Ｐ＞ ０．０５）；Ｈｏｌｔｅｒ检测，参麦组房性早搏数治疗后减少，而对照组化疗后有所增加，存在显著差异（Ｐ均＜ ０．０５），ＳＴ段压低及Ｔ波改变，两组对照及自身对照均有明显差异（Ｐ均＜ ０．０１）；心电图检查，参麦组有效率为９０％ ，对照组为１０％ ，自身对照组为８０％ ，参麦组与对照组比较有明显差异（Ｐ＜ ０．０１）。结论：参麦注射液可减轻化疗药物对心脏的毒性作用
Objective: To observe the protective effect of Shenmai injection on the heart during hematopoietic malignancy chemotherapy. METHODS: Twenty-five patients with hematopoietic malignancies complicated with cardiovascular disease were randomly divided into 3 groups: Shenmai Injection group (10 cases) started intravenous infusion of Shenmai injection at 40 to 60 ml for 1 time 3 hours before chemotherapy. d, shared for 10 days; set the control group (10 cases); self-control group (5 cases), the first chemotherapy without Shenmai injection, the second time with Shenmai injection. Results: There was no significant difference in heart function between the Shenmai group and the control group, and the self-control group before and after chemotherapy (P> 0.05). Holter test showed that the number of atrial premature beats in the Shenmai group decreased after treatment, but the control group after chemotherapy There was an increase, there were significant differences (P <0.05), ST depression and T wave changes, both groups and their own control were significantly different (P <0.01); ECG, Shen Mai group have The efficiency was 90%, the control group was 10%, and the self-control group was 80%. The Shenmai group was significantly different from the control group (P<0.01). Conclusion: Shenmai injection can reduce the toxic effects of chemotherapy drugs on the heart