局部进展期食管癌治愈率低,预后差,放化疗联合治疗的介入使传统的手术治疗的地位受到了挑战。目前局部进展期食管癌的治疗方法有多种,针对性放化疗(definitive chemoradiotherapy,DCRT)是其中之一,但哪种是最佳的治疗仍存有争议。DCRT被认为是不能手术和不能切除的局部进展期食管癌的标准治疗。本文就针对性放化疗的现状及进展作一综述。 Local advanced esophageal cancer cure rate is low, the prognosis is poor, the combination of radiotherapy and chemotherapy intervention so that the status of traditional surgical treatment has been challenged. Currently there are many treatments for locally advanced esophageal cancer, and definitive chemoradiotherapy (DCRT) is one of them, but the best treatment is still controversial. DCRT is considered a standard treatment for locally advanced esophageal cancer that is inoperable and unresectable. This article reviews the status and progress of targeted radiotherapy and chemotherapy.