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目的 了解表皮生长因子 (EGF)与消化性溃疡的发生、愈合之间的关系 ,探讨溃疡病的可能发生与愈合机理。方法 采用放免法检测成人与儿童消化性溃疡患者溃疡病不同时期血清、胃液和唾液EGF含量 ,并与胃炎患者及正常健康对照组作了比较。结果 消化性溃疡患者在溃疡活动期时 ,唾液、胃液中的EGF水平明显低于慢性胃炎组 ;在溃疡愈合期时 ,唾液、胃液、血清中的EGF水平升高 ,尤为胃液更为明显。结论 消化性溃疡患者存在EGF的分泌异常 ,EGF分泌水平的变化与消化性溃疡的发生与愈合有一定的关系。
Objective To understand the relationship between epidermal growth factor (EGF) and the occurrence and healing of peptic ulcer and to explore the possible occurrence and healing mechanism of ulcer disease. Methods The levels of EGF in serum, gastric juice and saliva of patients with peptic ulcer in adults and children with peptic ulcer were detected by radioimmunoassay. The levels of EGF were compared with those of patients with gastritis and healthy controls. Results In peptic ulcer patients, the levels of EGF in saliva and gastric juice were significantly lower than those in chronic gastritis group. In the healing period of ulcer, the levels of EGF in saliva, gastric juice and serum were increased, especially in gastric juice. Conclusions The secretion of EGF is abnormal in patients with peptic ulcer. The change of EGF secretion is related to the occurrence and healing of peptic ulcer.