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目的观察聚内酯微泡的微循环血流变学特征,评价微泡滞留的程度,滞留对局部血流动力学的影响。方法27只Wistar大鼠分为2组,分别经颈动脉和颈静脉注射不同剂量的荧光微泡,活体显微镜观察微泡在肠系膜微循环的流变学特点。结果动脉注射后微血管静止微泡的个数随剂量的增加而增多,600μl/kg剂量组静止微泡的发生率为0.85%(11/1300)。静脉注射聚内酯微泡后在所有30个光镜视野中未观察到微泡在微循环的阻塞。红细胞的流动速度与微泡的平均流速有很好的相关性(r=0.89,P<0.05)。结论聚内酯超声造影剂微血管流变学特性与红细胞相似,有极少微泡会暂时粘附嵌陷在小动脉或毛细血管。
Objective To observe the micro-circulation hemorheology of polylactone microbubbles and evaluate the degree of retention of microbubbles and the effect of retention on hemodynamics. Methods Twenty-seven Wistar rats were divided into two groups. Fluorescent microbubbles were injected into the carotid artery and jugular vein at different doses respectively. The rheological characteristics of the microvesicles in the mesenteric microcirculation were observed under a living microscope. Results The number of microvessel microbubbles increased with the increase of dose after arterial injection. The incidence of resting microbubbles in 600μl / kg group was 0.85% (11/1300). No microcephalic blockage in the microcirculation was observed in all 30 light microscopic fields after intravenous injection of the polylactone microbubbles. There was a good correlation between the flow rate of erythrocytes and the average flow velocity of microbubbles (r = 0.89, P <0.05). CONCLUSIONS: Polycaprolactone contrast agents have microvascular rheology similar to that of erythrocytes, with minimal microvesicles temporarily adhering to the arterioles or capillaries.