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目的 :探讨慢性阻塞性肺病 (COPD)患者血清血管紧张素 (A 、A )和醛固酮水平变化 ,相互间关系及其临床意义。方法 :采用放射免疫法测定了 76例 COPD患者和 30例健康对照组的血清血管紧张素 (A 、AII)和醛固酮 (ALD)水平 ,并进行统计分析。结果 :COPD组 A (2 .73± 0 .0 3ng/ LtALD(132 .2 6± 9.15ng/ L)水平显著高于对照组 (1.4 5± 0 .18ng/ L) 47.15± 2 .2 1n/ L) (t=2 .6 0 2 ,p<0 .0 5;t=4 .189,p<0 .0 1) ,A 水平无显著差异。 37例合并呼吸衰竭组血清 ALD水平显著高于 39例无呼吸衰竭组 p<0 .0 5) ;8例住院期间死亡者血清 ALD也显著高于好转出院者 (P<0 .0 5)。COPD患者中 ,血清 A 、AII和 ALD间呈显著正相关 (P均 <0 .0 5)。结论 :COPD患者存在着明显的 AI、AII和ALDII水平变化 ,而且三者间存在着一定的联系 ,测定其水平有助对 COPD患者病情严重程度和预后的判断。
Objective: To investigate the changes of serum angiotensin (A, A) and aldosterone levels in patients with chronic obstructive pulmonary disease (COPD) and their relationship with each other and their clinical significance. Methods: Serum levels of angiotensin (A, AII) and aldosterone (ALD) in 76 patients with COPD and 30 healthy controls were determined by radioimmunoassay and statistical analysis was performed. Results: The level of A (2.73 ± 0.30ng / LtALD (132.2 ± 9.15ng / L) in COPD group was significantly higher than that in control group (1.4 ± 0.18ng / L) 47.15 ± 2.21n / L (t = 2.602, p <0.05; t = 4.189, p <0.01). There was no significant difference in A level. Serum ALD levels in 37 patients with respiratory failure were significantly higher than those in 39 patients without respiratory failure (p <0.05). Serum ALD was significantly higher in 8 patients who died during hospitalization than those in discharged patients (P <0.05). Among COPD patients, there was a significant positive correlation between serum A, AII and ALD (all P <0.05). CONCLUSIONS: There are obvious changes of AI, AII and ALDII in patients with COPD, and there is a certain relationship between the three. The determination of their level will help judge the severity and prognosis of COPD patients.