呋喃西林是一种广谱的抗菌药物,它对革兰氏阳性及阴性细菌均有强大的抗菌作用。起初作为防腐、外用,及治兽类疾病,1953年苏联开始用它治疗细菌性痢疾(以下简称菌痢),治愈率达94%。1958年后,国内亦广泛用以治疗菌痢。一般文献报告治愈率约为48-92%,疗效显著。但是,由于应用呋喃西林发生了一些副作用,特别是多发性神经炎,恢复缓慢,遗留机能障碍,甚至可导致死亡,于是,有人曾提出该药不宜随便使用。五年来,我院使用呋喃西林治疗菌痢共1,209例,与合霉素、黄连素等药物分组比较,发现三种药物对各型菌痢第一疗程平均治愈率以呋喃西林为最高(76.48%),合霉素次之(65.81%),黄连素最低(58.7%)。呋喃 Nitrofurazone is a broad-spectrum antimicrobial drug that has a strong antibacterial effect on Gram-positive and -negative bacteria. Initially as a preservative, external use, and the treatment of animal diseases, the Soviet Union in 1953 began to treat it with bacillary dysentery (hereinafter referred to as bacillary dysentery), the cure rate was 94%. After 1958, the domestic is also widely used to treat bacillary dysentery. The general literature reported a cure rate of about 48-92%, with significant effect. However, some side effects, such as polyneuritis, slow recovery, residual dysfunction, and even death, have been reported as a result of the application of nitrofurazone. As a result, it has been suggested that this medicine should not be used casually. In the past five years, 1,209 cases of bacillary dysentery were treated with nitrofurazone in our hospital. Compared with the drugs such as combinomycin and berberine, the average cure rate of the three drugs on the first course of bacillary dysentery was nitrofurazone (76.48%), Clindamycin followed (65.81%), berberine lowest (58.7%). Furan