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目的:探讨心脏乳头状弹力纤维瘤的临床病理特征、诊断和鉴别诊断、治疗及预后特点,为临床诊断及治疗提供依据。方法:采用HE染色、免疫组织化学及特殊染色技术对10例原发性心脏乳头状弹力纤维瘤进行形态学研究,回顾性分析其临床资料及病理学特征。结果:镜下见肿瘤呈细乳头状结构,乳头轴心由弹力纤维构成,表面被覆单层扁平或立方上皮细胞,免疫组化:乳头状表面被覆的上皮Vim和CD34(+),乳头轴心则S-100蛋白(+),弹力纤维染色(+)。结论:心脏乳头状弹力纤维瘤患者缺乏特征性临床症状和体征,易与心脏相关疾病混淆。组织病理学特点,免疫组化标记及特殊染色有助于肿瘤的诊断和鉴别诊断。
Objective: To investigate the clinicopathological characteristics, diagnosis and differential diagnosis, treatment and prognosis of papillary fibroelastoma and to provide evidence for clinical diagnosis and treatment. Methods: Ten cases of primary papillary fibroelastoma were studied by HE staining, immunohistochemistry and special staining techniques. The clinical data and pathological features were retrospectively analyzed. Results: Microscopically, the tumor showed a fine papillary structure. The axis of the papilla was composed of elastic fibers. The surface of the papilla was covered with flattened or cuboidal epithelial cells. Immunohistochemistry: Vim and CD34 (+) epithelium covered by papillary surface, S-100 protein (+), elastic fiber staining (+). CONCLUSIONS: Patients with papillary fibroids lack specific clinical signs and symptoms and are easily confused with heart-related diseases. Histopathological features, immunohistochemical markers and special staining contribute to the diagnosis and differential diagnosis of tumors.