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目的:探讨脐带间充质干细胞移植治疗对脑瘫患儿运动功能的影响极其应用价值。方法:25例脑瘫患者给予脐带间充质干细胞移植治疗,移植方法采用静脉输注联合腰穿鞘内注射的方法。移植术前及移植术后定期采用粗大运动评估量表(Gross MotorFunction Measure,GMFM)及Berg平衡量表(Berg Balance Scale,BBS)对运动功能的改善情况进行评估并进行综合分析。结果:移植术后6月25例脑瘫患儿中有22例患者主观上运动功能较前有明显好转,客观上25例患者GFMF与BSS与术前比较有明显改善(P<0.05),随访6月未发现与移植相关的副作用。结论:脐带间充质干细胞移植是一种安全有效的治疗方法,可在一定程度上改善脑瘫患者的后遗症,提高脑瘫患者的运动功能和生活质量。
Objective: To explore the application of umbilical cord mesenchymal stem cell transplantation in children with cerebral palsy motor function extremely useful. Methods: Twenty-five patients with cerebral palsy were treated with umbilical cord mesenchymal stem cells transplantation. The transplantation method was intravenous infusion combined with lumbar puncture intrathecal injection. The improvement of motor function was evaluated and analyzed by Gross Motor Function Measure (GMFM) and Berg Balance Scale (BBS) regularly before and after transplantation. Results: In 25 children with cerebral palsy after transplantation, the subjective motor function of 25 children with cerebral palsy improved significantly compared with those before. The objective GFMF and BSS in 25 patients were significantly improved compared with that before operation (P <0.05) No side effects associated with transplantation were found during the month. Conclusion: Umbilical cord mesenchymal stem cell transplantation is a safe and effective treatment, which can improve the sequelae of cerebral palsy patients to a certain extent and improve the motor function and quality of life in patients with cerebral palsy.