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Objective:To investigate the role of Runx3 protein and TGF-β_1 in the pathogenesis of irritable bowel syndrome(IBS),as well as the correlation of these two proteins.Methods:Colonic tissue was collected from patients with IBS and normal persons.The colonic expression of Runx3 protein and TGF-β_1 was detected with immunohislochemistry method.Semi-quantitative analysis was used to evaluate the staining degree of these two proteins.Results:Compared with their counterparts,patients with IBS did not show any changes in the colonic expression of Runx3 protein and TGF-β_1(P>0.05).Interestingly,there was a significant correlation between Runx3 protein and TGF-β_1 in patients with IBS(P<0.05).Conclusions:The role of Runx3 protein and TGF-β_1 in the pathogenesis of IBS remains to be further studied.
Objective: To investigate the role of Runx3 protein and TGF-β_1 in the pathogenesis of irritable bowel syndrome (IBS), as well as the correlation of these two proteins. Methods: Colonic tissue was collected from patients with IBS and normal persons. Colonic expression of Runx3 protein and TGF-β_1 was detected with immunohislochemistry method. Send-quantitative analysis was used to evaluate the staining degree of these two proteins. Results: Compared with your counterparts, patients with IBS did not show any changes in the colonic expression of Runx3 protein and TGF-β_1 (P> 0.05). Interestingly, there was a significant correlation between Runx3 protein and TGF-β_1 in patients with IBS (P <0.05) .Conclusions: The role of Runx3 protein and TGF- of IBS remains to be further studied.