褪黑素(melatonin,MT)是松果体合成和分泌的一种神经内分泌激素,不仅参与生物周期性节律、神经-内分泌-免疫调节、镇静、催眠等,而且在Alzheimer病、失眠、抑郁症等多种疾病中具有治疗作用。同时,在许多有关癫的临床和动物实验研究中发现MT有抗和促的双重作用。本文从MT的生理活性入手,就近5年来有关MT的抗和促作用及可能机制做一综述。 Melatonin (MT) is a kind of neuroendocrine hormone synthesized and secreted by pineal gland. It not only participates in biological circadian rhythm, neuroendocrine-immune regulation, sedation and hypnosis, but also plays an important role in Alzheimer’s disease, insomnia and depression And other diseases have a therapeutic effect. At the same time, MT has been found to play a dual role in anti-inflammatory and anti-inflammatory effects in many clinical and animal studies of epilepsy. In this paper, starting from the physiological activity of MT, MTT in the past five years on the anti-tuberculosis and promote intestinal role and possible mechanisms to do a review.