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慢性鼻窦炎的红霉素疗法原则上剂量为600mg/日(小儿10mg/kg/日),给药3个月以上。90%以上病例均有不同程度的好转,疗效优于以往的药物治疗。鼻溢液、后鼻孔溢液等鼻粘膜、鼻窦粘膜过度分泌症状较鼻粘膜肿胀及嗅觉障碍改善尤为显著。红霉素小剂量长期疗法的特点:①细菌对红霉素是否敏感与疗效无关;②一般需用药2～3个月始见效;③常规剂量的半量即可奏效;④小儿疗效较成人稍差;⑤有无下呼吸道症状与疗效无关。副作用:少数病例可见一过性轻度肝功能损害、胃痛,停药即缓解。大环内酯类抗生素阻碍细菌蛋白质合成的作用不能解释本疗法的机制。慢性鼻窦炎似弥漫性毛细支气管炎,均系呼吸道粘膜的顽固感染,临床表现相似,红霉素均可控制,
In principle, the dose of erythromycin for chronic sinusitis is 600mg / day (10mg / kg / day for children) for more than 3 months. More than 90% of cases have different degrees of improvement, the effect is better than the previous drug treatment. Nasal discharge, nasal discharge and other nasal mucosa, sinus mucosa over the secretion of symptoms than the nasal mucosa swelling and improvement of the sense of smell is particularly significant. Erythromycin low-dose long-term therapy features: ① whether the bacteria sensitive to erythromycin has nothing to do with the efficacy; ② generally require medication for 2 to 3 months to begin effective; ③ half the dose can be effective; ④ pediatric efficacy is slightly worse than adults ; ⑤ with or without lower respiratory tract symptoms has nothing to do with the efficacy. Side effects: a few cases of transient mild liver damage, stomach pain, withdrawal is relieved. The effect of macrolide antibiotics on bacterial protein synthesis can not explain the mechanism of this therapy. Chronic sinusitis-like diffuse bronchiolitis, are stubborn respiratory tract mucosal infection, clinical manifestations similar to erythromycin can be controlled,