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副粘病毒科中的呼吸道合胞病毒(RSV)和3型副流感病毒(PIV_3)可引起婴幼儿细支气管炎和肺炎,PIV_3还引起哮吼,由这两种病毒导致住院治疗的婴幼儿占所有因呼吸道疾病住院儿童的30%.迄今尚无获准使用的预防这两种病毒感染的疫苗.1994年3月27日,全球疫苗规划处(GPV)在瑞士尼翁组织了一次专题讨论会,回顾了这两种疫苗的研究状况,并探索能用于预防RSV和PIV_3所致疾病的新免疫接种方法.WHO希望评价用RSV和PIV_3的cDNA克隆拯救感染性病毒的方法学建立方面的进展.该技术一旦建立,对研制新一代候选疫苗和阐明现有疫苗减毒作用的遗传学基础均具有重要价值.
Respiratory syncytial virus (RSV) and Parainfluenza type 3 (PIV_3) in Paramyxoviridae cause bronchiolitis and pneumonia in infants and young children, and PIV_3 also causes croaks, infants and young children who are hospitalized for these two viruses account for All children hospitalized with respiratory diseases account for 30% of children. To date, no vaccine has been approved for the prevention of these two infections. On March 27, 1994, the Global Vaccine Planning Unit (GPV) organized a symposium in Nyon, Switzerland, The state of the research on these two vaccines was reviewed and new immunization methods that could be used to prevent diseases caused by RSV and PIV_3 were sought and WHO hoped to evaluate the methodological progress in the rescue of infectious viruses with cDNA clones of RSV and PIV_3. Once established, this technology is of great value to developing a new generation of vaccine candidates and to elucidating the genetic basis of the attenuation of existing vaccines.