食管鳞癌是一种多因素的疾病,除了环境因素可以影响食管癌发生和发展,分子水平的基因改变是近年研究的热点。近年基因芯片技术的发展,已发现众多基因,如β-catenin、wnt1、p53、cyclinD1以及EGFR等基因表达的改变与食管鳞癌的发生、发展或预后相关,从而可更好地寻找判断预后的分子指标,具有广阔的应用前景,但其与影响食管鳞癌预后的众多因素之间的关系及其与临床病理的关系以及应用,仍需进一步研究。 Esophageal squamous cell carcinoma is a multifactorial disease, in addition to environmental factors can affect the occurrence and development of esophageal cancer, molecular level of gene changes in recent years, hot spots. In recent years, the development of gene chip technology has found that many genes such as β-catenin, wnt1, p53, cyclinD1 and EGFR and other gene expression changes associated with the occurrence, development or prognosis of esophageal squamous cell carcinoma, which can better find the prognosis Molecular indicators, has broad application prospects, but its relationship with many factors affecting the prognosis of esophageal squamous cell carcinoma and its relationship with clinicopathological and applications, still need further study.