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目的探讨转酮醇酶1(TKTL1)在胃癌组织中的表达及其意义。方法采用免疫组化SP法检测TKTL1蛋白在胃癌组织、癌旁组织和正常胃黏膜组织中的表达情况,分析它们与胃癌临床病理特征之间的关系。结果TKTL1在胃癌组织中呈高表达(P<0.0 1),其高表达与胃癌的浸润深度、肿瘤TNM分期以及淋巴结转移有关;上述3特征的分组间差异均有统计学意义(P<0.0 5)。结论TKTL1的高表达与胃癌的发展和转移关系密切。
Objective To investigate the expression of transketolase 1 (TKTL1) in gastric carcinoma and its significance. Methods Immunohistochemical SP method was used to detect the expression of TKTL1 protein in gastric cancer tissues, adjacent non-cancerous tissues and normal gastric mucosa tissues, and to analyze their relationship with the clinicopathological features of gastric cancer. Results The high expression of TKTL1 was found in gastric carcinoma (P <0.01). The high expression of TKTL1 was associated with the depth of invasion, TNM stage and lymph node metastasis of gastric cancer. The differences among the three groups were statistically significant (P <0.0 5 ). Conclusion The high expression of TKTL1 is closely related to the development and metastasis of gastric cancer.