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作者选未经治疗的常年性鼻炎患者10名(男、女名5名)。坐位头前倾吸去鼻腔积存分泌物后,将浸有屋尘抗原的圆形滤纸片贴在下鼻甲前端,然后收集鼻分泌物共10分钟。测定鼻分泌物容量及重量后,采用高效能液相色谱法结合放射免疫测定进行白细胞三烯 C_4和D_4的测定。结果:抗原激发前鼻分泌物中 LTC_4为0.41±0.22ng/ml,LTD_4为0.31±0.09ng/ml;激发后 LTC_4为2.43±0.85ng/ml,LTD_4为2.72±0.52ng/ml,差别有统计学意义。用 LTC_4和 LTD_4对22名患者进行了鼻粘膜激发试验。另选17名作为对照。将荧光素染色线的一端贴在下鼻甲上,观察其被鼻分泌物浸
The author selected untreated perennial rhinitis patients 10 (male and female names 5). Sit down the head and sucked to the nasal cavity to accumulate secretions, the house-dust antigen-coated round filter paper attached to the inferior turbinate front, and then collect the nasal discharge for 10 minutes. Determination of nasal secretion capacity and weight, using high performance liquid chromatography combined with radioimmunoassay determination of leukotriene C_4 and D_4. Results: The levels of LTC_4 in nasal secretions before antigen challenge were 0.41 ± 0.22ng / ml and those of LTD_4 were 0.31 ± 0.09ng / ml. The levels of LTC_4 after stimulation were 2.43 ± 0.85ng / ml and LTD_4 was 2.72 ± 0.52ng / ml Significance of learning. Twenty-two patients underwent nasal mucosal challenge with LTC_4 and LTD_4. Another 17 as a control. The end of the fluorescein staining line affixed to the inferior turbinate, observe its nasal secretions soaked