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目的探讨ＩｇＡ肾病（ＩｇＡＮ）临床表现与超微病理改变之间的联系。方法对１２２例肾活检标本进行系统的超微结构观察，以半定量方法对各项超微病变进行分级，并和肾小球损伤程度及临床分型相对照，进行统计学处理。结果肾小球系膜旁区半球形沉着物、基膜内皮下或上皮下沉着物、系膜溶解、系膜细胞插入和基膜异常均与肾小球损伤程度呈正比。系膜溶解以外的各种超微病变，其程度在不同临床类型中有显著差异。结论ＩｇＡＮ众多临床表现各有其相应的超微结构病变，其程度对预后判断及指导治疗具有重要意义
Objective To investigate the relationship between the clinical manifestations of IgA nephropathy (IgAN) and ultrastructural pathology. Methods 122 cases of renal biopsy specimens were systematically observed by ultrastructure, and all the superficial lesions were graded by semi-quantitative method. The results were compared with the degree of glomerular injury and clinical classification, and were statistically analyzed. Results Glomerular mesangial hemispherical deposits, subepithelial or subepithelial submucosa, mesangial lysis, mesangial cell insertion and basal membrane abnormalities were all in direct proportion to the degree of glomerular injury. Mesangial lysis in addition to a variety of ultra-small lesions, the extent of different clinical types were significantly different. Conclusion Many clinical manifestations of IgAN have their corresponding ultrastructural lesions, the extent of which is of great significance for the prognosis and guidance