为探讨雌二醇对去势大鼠颈总动脉球囊损伤后内膜增生的影响 ,选择 8- 10周S -D大鼠 ,雌性、雄性各 2 1只 ,各分三组 :非去势对照组 (n =7)、去势对照组 (n =7)和实验组 (n =7,去势 +雌二醇 )。腹腔注射雌二醇三天后 ,以 2 .0F经皮腔内冠状动脉成形术球囊损伤左颈总动脉。动脉损伤两周后处死大鼠 ,测量内膜面积、内膜面积与中膜面积的比值。结果发现 ,雄性实验组内膜面积 ( 0 .0 72± 0 .0 2 0mm2 )、内膜面积与中膜面积的比值 ( 0 .5 33±0 .0 37)均显著小于非去势对照组 ( 0 .110± 0 .0 18mm2 和 0 .740± 0 .0 5 1,P均 <0 .0 1)和去势对照组 ( 0 .0 98± 0 .0 14mm2 和 0 .70 1± 0 .0 40 ,P均 <0 .0 5 )。雌性实验组内膜面积 ( 0 .0 6 1± 0 .0 15mm2 )、内膜面积与中膜面积比值 ( 0 .5 2 5±0 .0 30 )均显著小于去势对照组 ( 0 .10 1± 0 .0 18mm2 和 0 .710± 0 .0 31,P均 <0 .0 1) ,但与非去势对照组 ( 0 .0 78± 0 .0 12mm2 和 0 .6 19± 0 .0 41)差异不显著 (P均 >0 .0 5 )。提示雌二醇能抑制去势大鼠动脉损伤后内膜增生 To investigate the effect of estradiol on intimal hyperplasia after carotid artery balloon injury in ovariectomized rats, twenty-one S-D rats, 8- and 10-week-old were selected and divided into three groups: non-castrated Control group (n = 7), castration control group (n = 7) and experimental group (n = 7, castration + estradiol). After three days of intraperitoneal injection of estradiol, the left common carotid artery was injured by 2 .0F percutaneous transluminal coronary angioplasty balloon. Rats were sacrificed two weeks after arterial injury, and the ratio of intima area to intima area to medial area was measured. The results showed that the ratio of intima area (0.72 ± 0.220mm2) and intima-media area (0.0533 ± 0.037) in male experimental group was significantly lower than that in non-castration control group (0 .110 ± 0. 0 18mm2 and 0 .740 ± 0. 0 5 1, P all <0.01) and the castration control group (0.098 ± 0. 0 14mm2 and 0.70 1 ± 0 .0 40, P <0.05). The ratio of intimal area to intima area (0. 52 ± 0. 0 30) in the female experimental group was significantly lower than that in the castrate control group (0.010 ± 0.015 mm 2) 1 ± 0. 0 18mm2 and 0. 710 ± 0. 0 31, P all <0.01), but with the non-castration control group (0. 0 78 ± 0. 0 12mm2 and 0 6 19 ± 0. 0 41) was not significantly different (P> 0.05). These results suggest that estradiol can inhibit intimal hyperplasia after arterial injury in ovariectomized rats