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目的评价加巴喷丁联合甲钴胺对2型糖尿病性周围神经病变(diabetes peripheral neuropathy,DPN)的疗效。方法将2015年1—10月的DPN患者138例随机分为三组。甲钴胺组(n=43):给予甲钴胺0.5 mg,肌肉注射,1次/d;加巴喷丁组(n=47):口服加巴喷丁300 mg,2次/d;联合治疗组(n=48):在应用甲钴胺的基础上给予口服加巴喷丁300mg,2次/d,疗程均为14 d。观察各组患者治疗前后症状、体征的变化。组间比较计量资料采用t检验,计数资料比较用χ~2检验,P<0.05为差异有统计学意义。结果加巴喷丁组总有效率(68.1%)显著高于甲钴胺组总有效率(46.5%),联合治疗组总有效率(75.0%)较加巴喷丁组及甲钴胺组疗效更好,对比差异均有统计学意义(均P<0.05)。结论加巴喷丁与甲钴胺联合治疗DPN疗效优于单用加巴喷丁或甲钴胺,且安全性好。
Objective To evaluate the efficacy of gabapentin combined with mecobalamin in type 2 diabetic peripheral neuropathy (DPN). Methods One hundred and thirteen DPN patients from January to October in 2015 were randomly divided into three groups. Mecobalamin (n = 43): 0.5 mg of methylcobalamin administered intramuscularly once a day; gabapentin group (n = 47): gabapentin 300 mg twice daily; ): On the basis of application of mecobalamin given oral gabapentin 300mg, 2 times / d, treatment were 14 d. The changes of symptoms and signs in each group before and after treatment were observed. Comparison of measurement data between groups using t test, count data were compared using χ ~ 2 test, P <0.05 for the difference was statistically significant. Results The total effective rate (68.1%) in the gabapentin group was significantly higher than that in the methylcobalamin group (46.5%). The total effective rate (75.0%) in the combination group was better than that in the gabapentin group and the methylcobalamin group There was statistical significance (all P <0.05). Conclusion The combination of gabapentin and mecobalamin is superior to gabapentin or mecobalamin in the treatment of DPN, and its safety is good.