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应用小鼠骨髓嗜多染红细胞(PCE)微核试验方法,研究麦草粉与绿茶对胃癌高发区鱼露经亚硝化后致突变的抑制作用。结果表明,20%麦草粉、10%绿茶可降低亚硝化鱼露所致的小鼠微核率增高的作用(P<0.01)。将按成分换算后相当于0.02%VC的20%麦草粉干预组和0.002%VC的10%绿茶干预组与0.1%VC干预对照组比较,微核出现率没有显著差异(P>0.05)。提示麦草粉、绿茶的抑制作用尚与VC外的其他活性成分有关。两者可能有希望成为喜食鱼露的胃癌高发区居民安全无毒又易被接受的天然保护食物。
Micronucleus test of mouse bone marrow polychromatic erythrocytes (PCE) was used to study the inhibitory effect of wheat straw powder and green tea on nitrite-induced mutagenesis of fish dew in the high incidence area of gastric cancer. The results showed that 20% wheat straw powder and 10% green tea reduced the micronuclei of mice induced by nitrosated fish sauce (P <0.01). There was no significant difference in the incidence of micronuclei when compared with the 20% wheat straw intervened group equivalent to 0.02% VC and the 10% green tea intercalated group with 0.002% VC after conversion according to the composition and the 0.1% VC intervened control group P> 0.05). Tip wheat straw powder, the inhibitory effect of green tea is still with VC other active ingredients. Both may have the potential to become natural protected foods that are safe, non-toxic and readily acceptable to residents of high incidence areas of stomach cancer who like to eat fish sauce.