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14只狗沿小肠浆膜面埋植4对Ag—Agcl双极电极,记录小肠的电活动;并于侧脑室插入不锈钢套管作为中枢给药的途径。结果发现(1)侧脑室给予多巴胺10ug/kg后,小肠各部几乎同时发生强烈的峰电活动,持续1～5分钟,并在74.8％的实验中出现呕吐。消化间期综合肌电(IDMEC)周期和Ⅱ相时程明显延长。(2)阻断外周交感神经的α和β受体后,不影响多巴胺的中枢效应。切除迷走神经后,多巴胺引起的强烈峰电活动和呕吐消失,但对IDMEC的影响不变。(3)侧脑室给予乙酰胆碱12ug/kg后,IDMEC周期、Ⅱ相和Ⅰ相时程均明显缩短;阻断交感神经受体和切除迷走神经后,乙酰胆碱的上述效应仍然存在。以上结果提示,中枢神经系统内的多巴胺机制和乙酰胆碱能机制的互相拮抗协调,使小肠的肌电活动保持着正常的生理状态。
Fourteen dogs were implanted with four pairs of Ag-Ag bip bipolar electrodes on the serosal surface of the small intestine to record the electrical activity of the small intestine. A stainless steel cannula was inserted into the lateral ventricle as a central route of administration. The results showed that: (1) After administration of dopamine 10ug / kg into the lateral ventricle, all the parts of the small intestine developed strong peak electrical activity almost simultaneously for 1 to 5 minutes and vomiting in 74.8% of the experiments. Digestive intermittent period electromyography (IDMEC) cycle and Ⅱ phase duration significantly prolonged. (2) blocking the peripheral sympathetic α and β receptors, does not affect the central effect of dopamine. After excision of the vagus nerve, the intense peak electrical activity and vomiting caused by dopamine disappeared, but the effect on IDMEC remained unchanged. (3) After administration of acetylcholine (12ug / kg) in the lateral ventricle, the duration of IDMEC, phase Ⅱ and phase Ⅰ were significantly shortened. After blocking the sympathetic nerve receptors and excising the vagus nerve, the above effects of acetylcholine still existed. The above results suggest that the dopamine mechanism in the central nervous system and acetylcholine mechanism of mutual antagonism and coordination, so that the small intestine myoelectrical activity to maintain the normal physiological state.